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Inject for 15 seconds

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    Part 2

    Inject for 15 seconds

6Pull off the cap

Do not remove the cap until you are ready to inject.

7Inject SAPHNELO for 15 seconds

What to know first

Inject using SAPHNELO PEN by following the steps in figures a, b, c, and d.

To deliver a full dose, press and hold the pre-filled pen for about 15 seconds until the green plunger fills the viewing window. Do not move or change the position of SAPHNELO PEN after the injection has started.

You may hear a first ‘click’ at the start of the injection and a second ‘click’ at the end of the injection.

Position SAPHNELO pen.

Place the green needle guard flat against your skin (90-degree angle). Make sure you can see the viewing window.

Press down firmly and hold against skin.

You may hear the first ‘click’ right away. This tells you the injection has started. The green plunger will move down in the viewing window.

Hold down firmly for about 15 seconds.

The green plunger will fill the viewing window. You may hear the second ‘click’ at the end of injection.

After you have completed your injection, lift SAPHNELO PEN straight up.

The green needle guard will slide down and lock into place over the needle.

Video: Summary of injection steps

8Check the viewing window

Check the viewing window to make sure all the medicine has been injected.

If the green plunger does not fill the viewing window, you may not have received the full dose. If this happens or if you have any other concerns, contact your healthcare provider.

9Check the injection site

There may be a small amount of blood or liquid at the injection site. This is normal.

If needed, press a cotton ball or gauze on the area and apply a small bandage. Do not rub the injection site.

By completing this registration, I confirm that I am at least 18 years old, agree to receive information about SAPHNELO, and may receive information about other immunology medicines and services related to my condition which includes, but is not limited to, educational and promotional materials, special offers and services and for market research purposes, which includes contacting me to participate in focus groups, surveys or interviews. This may include AstraZeneca or a third party working on AstraZeneca's behalf contacting me by telephone, e-mail and text message regarding AstraZeneca Support Programs that may be of interest to me. Information provided by AstraZeneca does not take the place of talking to your healthcare provider about your treatment or condition. If you no longer want to receive health-related materials, call 1-800-236-9933. Please visit www.azprivacynotice.com to review our Privacy Notice.

By providing your phone number, you are opting in to receive updates and support messages from SAPHNELO. Text STOP to opt out. Text HELP for help. Message frequency will vary. Message and data rates may apply. For more information, visit Privacy Notice or Terms & Conditions.

IMPORTANT SAFETY INFORMATIONWhite CaratWhite Carat

  • Do not use SAPHNELO if you are allergic to anifrolumab-fnia or to any of the ingredients
  • Before you receive SAPHNELO, tell your healthcare provider about all of your medical conditions, including if you:
    •  Think you have an infection or have an infection that keeps coming back
    •  Are scheduled to receive a vaccination or if you think you may need a vaccination. You should not receive live vaccines during treatment with SAPHNELO
    •  Have or have had cancer
    •  Are receiving other biologic medicines or monoclonal antibodies
    •  Are pregnant or plan to become pregnant. It is not known if SAPHNELO will harm your unborn baby. Tell your healthcare provider if you are, might be, or plan to become pregnant during treatment with SAPHNELO
      • Pregnancy exposure registry monitors pregnancy outcomes in women exposed to SAPHNELO. You can find out more information about the registry by calling AstraZeneca at 1-877-693-9268
    •  Are breastfeeding or plan to breastfeed. It is not known if SAPHNELO passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SAPHNELO may affect the way other medicines work, and other medicines may affect how SAPHNELO works.

SAPHNELO may cause serious side effects, including:

  • Serious infections: SAPHNELO can lower the ability of your immune system to fight infections. You may be at a higher risk of developing respiratory infections and shingles (herpes zoster) during treatment with SAPHNELO. Infections could be serious, leading to hospitalization or death. Tell your healthcare provider right away if you have any of the following symptoms of an infection:
    • fever, sweating, or chills
    • muscle aches
    • cough
    • shortness of breath
    • burning when urinating
    • urinating more often
    • diarrhea or stomach pain
    • warm, red, or painful skin or sores on your body
  • Allergic (hypersensitivity) reactions, including anaphylaxis: Serious allergic reactions can happen during or after SAPHNELO administration. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of a serious allergic reaction:
    •  swelling of your face, mouth, and tongue
    •  breathing problems
    •  fainting or dizziness
    •  feeling lightheaded (low blood pressure)
  • Cancer: SAPHNELO may reduce the activity of your immune system. Medicines that affect the immune system may increase your risk of certain cancers

The most common side effects of SAPHNELO include:

  •  Upper respiratory infections
  •  Bronchitis
  •  Infusion reactions (when given intravenously)
  •  Shingles (herpes zoster)
  •  Cough

These are not all the possible side effects of SAPHNELO. Call your healthcare provider for medical advice about side effects.

What is SAPHNELO?

SAPHNELO is a prescription medicine used to treat adults with moderate to severe systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines.

It is not known if SAPHNELO is effective in patients with severe active lupus nephritis or severe active central nervous system lupus. It is not known if SAPHNELO is safe and effective in patients under 18 years of age.

Please see full Prescribing Information, including Patient Information.

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IMPORTANT SAFETY INFORMATION

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