IV INFUSION

SAPHNELO as an intravenous (IV) infusion can fit into your monthly routine, as it is given at the same dose every 4 weeks over a 30-minute time period, in addition to your other lupus medications.

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WHAT YOU MAY EXPECT

BEFORE STARTING SAPHNELO

PREPARING FOR YOUR FIRST INFUSION

AFTER YOUR INFUSION

WHAT YOU MAY EXPECT

The SAPHNELO IV infusion is given by your healthcare team every 4 weeks.

Administered by your healthcare team through a needle placed in a vein (intravenous or IV infusion)

Given at your doctor’s office, a hospital, or at an infusion center. Your healthcare team will advise you on the location for treatment

Takes about 30 minutes to give you the full dose of SAPHNELO (300 mg). Your healthcare team will advise you on the time needed prior to and following your infusion

self-injection
Not what you’re looking for? SAPHNELO is also available as a once-weekly self-injection.
Learn more about the self-injection process using the SAPHNELO Pen.

WHAT TO KNOW BEFORE STARTING SAPHNELO

There are a few topics you should discuss with your doctor before receiving your first SAPHNELO infusion.

YOUR MEDICAL CONDITIONS

THE MEDICINES YOU TAKE

IF YOU'RE PREGNANT OR BREASTFEEDING, OR PLAN TO BE

PREPARING FOR YOUR FIRST SAPHNELO INFUSION

Trying something new for the first time can be nerve-racking but being prepared can help keep your mind at ease. Follow these steps and your healthcare team’s instructions to help get treatment started on the right foot.

1

Prepare a list of all the medicines you take and bring it with you

2

Confirm the location of your appointment and plan to get there early

3

Bring your go-to entertainment with you to pass the time during your SAPHNELO infusion

Talk to your healthcare team or infusion center team for detailed instructions.

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SAPHNELO INFUSIONS TAKE APPROXIMATELY

30 MINUTES

Talk to your healthcare team or infusion center team for detailed instructions.

LOOKING FOR AN INFUSION CENTER?

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LOOKING FOR AN INFUSION CENTER?

If you and your rheumatologist have decided that SAPHNELO is right for you, the National Infusion Center Association (NICA) is a public resource that may help you locate an infusion center. Check out this external resource to locate a center near you.

FIND A CENTER NEAR YOU

GET READY WITH LYNETT MARIE

Watch Lynett Marie, a real SAPHNELO patient, prepare for her SAPHNELO infusion and discover how she fits it into her routine with ease, positivity, and gratitude.

PLAY THE VIDEO
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Follow along with Lynett Marie, a real SAPHNELO patient, as she gets ready for her SAPHNELO infusion.

PLAY THE VIDEO

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WHAT TO KNOW BEFORE YOU GO!

Learn about the SAPHNELO infusion process and find tips on preparing for your first appointment. This document can help you understand what you may expect before, during, and after receiving SAPHNELO.

ENGLISH ESPAÑOL

WHAT COMES NEXT?

After your first infusion, SAPHNELO will usually be given one time every 4 weeks. Your healthcare team will advise you on scheduling future appointments so you can stay on track with your lupus treatment plan.

Four-Week Dose Calendar IconFour-Week Dose Calendar IconTHE SAME DOSE
EVERY
4WEEKS

If you miss an appointment, call your healthcare provider as soon as possible to reschedule your appointment.

KEEP EXPLORING

SUPPORT & AFFORDABILITY

Explore the support programs designed to help you start and stay on SAPHNELO.

SUPPORT & AFFORDABILITY
SUPPORT RESOURCES

Find helpful information and resources about SAPHNELO in one place.

SUPPORT RESOURCES

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IMPORTANT SAFETY INFORMATIONWhite CaratWhite Carat

  • Do not use SAPHNELO if you are allergic to anifrolumab-fnia or to any of the ingredients
  • Before you receive SAPHNELO, tell your healthcare provider about all of your medical conditions, including if you:
    •  Think you have an infection or have an infection that keeps coming back
    •  Are scheduled to receive a vaccination or if you think you may need a vaccination. You should not receive live vaccines during treatment with SAPHNELO
    •  Have or have had cancer
    •  Are receiving other biologic medicines or monoclonal antibodies
    •  Are pregnant or plan to become pregnant. It is not known if SAPHNELO will harm your unborn baby. Tell your healthcare provider if you are, might be, or plan to become pregnant during treatment with SAPHNELO
      • Pregnancy exposure registry monitors pregnancy outcomes in women exposed to SAPHNELO. You can find out more information about the registry by calling AstraZeneca at 1-877-693-9268
    •  Are breastfeeding or plan to breastfeed. It is not known if SAPHNELO passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SAPHNELO may affect the way other medicines work, and other medicines may affect how SAPHNELO works.

SAPHNELO may cause serious side effects, including:

  • Serious infections: SAPHNELO can lower the ability of your immune system to fight infections. You may be at a higher risk of developing respiratory infections and shingles (herpes zoster) during treatment with SAPHNELO. Infections could be serious, leading to hospitalization or death. Tell your healthcare provider right away if you have any of the following symptoms of an infection:
    • fever, sweating, or chills
    • muscle aches
    • cough
    • shortness of breath
    • burning when urinating
    • urinating more often
    • diarrhea or stomach pain
    • warm, red, or painful skin or sores on your body
  • Allergic (hypersensitivity) reactions, including anaphylaxis: Serious allergic reactions can happen during or after SAPHNELO administration. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of a serious allergic reaction:
    •  swelling of your face, mouth, and tongue
    •  breathing problems
    •  fainting or dizziness
    •  feeling lightheaded (low blood pressure)
  • Cancer: SAPHNELO may reduce the activity of your immune system. Medicines that affect the immune system may increase your risk of certain cancers

The most common side effects of SAPHNELO include:

  •  Upper respiratory infections
  •  Bronchitis
  •  Infusion reactions (when given intravenously)
  •  Shingles (herpes zoster)
  •  Cough

These are not all the possible side effects of SAPHNELO. Call your healthcare provider for medical advice about side effects.

What is SAPHNELO?

SAPHNELO is a prescription medicine used to treat adults with moderate to severe systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines.

It is not known if SAPHNELO is effective in patients with severe active lupus nephritis or severe active central nervous system lupus. It is not known if SAPHNELO is safe and effective in patients under 18 years of age.

Please see full Prescribing Information, including Patient Information.

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IMPORTANT SAFETY INFORMATION

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