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Prepare

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    Part 1

    Prepare

1 GATHER SUPPLIES

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See Step 10 for instructions on how to throw away (dispose of) the used SAPHNELO PEN.

2 Prepare to use your SAPHNELO PEN

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Select a clean, well-lit, flat work surface, such as a table.

Check the expiration date (EXP) on the carton. Check the carton for damage.

Let SAPHNELO PEN come to room temperature for 60 minutes before injecting. Keep SAPHNELO PEN in original carton to protect from light.

  • Do not use if the expiration date on the carton has passed, or if the carton looks damaged.
  • Do not warm SAPHNELO PEN in any other way. For example, do not warm it in a microwave, hot water, direct sunlight, or near other heat sources.

3 Check the liquid

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Open the carton and remove SAPHNELO PEN by gently grasping the middle of the device.

Check the expiration date on SAPHNELO PEN. Check SAPHNELO PEN for damage.

Check the liquid through the viewing window. The liquid should be clear and colorless to slightly yellow. It is normal to see small air bubbles in the liquid.

  • Do not use if the expiration date on the pen has passed, or if the pen is damaged.
  • Do not use if the liquid is cloudy, discolored, or contains visible particles.
  • Do not try to remove the air bubbles.

4 Choose an injection site

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You or your caregiver can inject in the front of your thigh or the lower part of your stomach (abdomen).

A caregiver may also inject you in your upper arm. Do not try to inject yourself in the upper arm.

Choose an injection site that is at least 1 inch (3 cm) away from where you last injected.

    Do not inject:

  • into the 2-inch (5 cm) area around your belly button.
  • where skin is red, warm, tender, bruised, scaly, or hard.
  • into scarred, damaged, discolored, or tattooed skin.
  • through clothing.

5 Wash your hands and clean the injection site

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Wash your hands well with soap and water.

Clean the injection site with an alcohol wipe or with soap and water. Let the site air dry.

    Do not:

  • touch the cleaned injection site again.
  • blow on the cleaned injection site.

By completing this registration, I confirm that I am at least 18 years old, agree to receive information about SAPHNELO, and may receive information about other immunology medicines and services related to my condition which includes, but is not limited to, educational and promotional materials, special offers and services and for market research purposes, which includes contacting me to participate in focus groups, surveys or interviews. This may include AstraZeneca or a third party working on AstraZeneca's behalf contacting me by telephone, e-mail and text message regarding AstraZeneca Support Programs that may be of interest to me. Information provided by AstraZeneca does not take the place of talking to your healthcare provider about your treatment or condition. If you no longer want to receive health-related materials, call 1-800-236-9933. Please visit www.azprivacynotice.com to review our Privacy Notice.

By providing your phone number, you are opting in to receive updates and support messages from SAPHNELO. Text STOP to opt out. Text HELP for help. Message frequency will vary. Message and data rates may apply. For more information, visit Privacy Notice or Terms & Conditions.

IMPORTANT SAFETY INFORMATIONWhite CaratWhite Carat

  • Do not use SAPHNELO if you are allergic to anifrolumab-fnia or to any of the ingredients
  • Before you receive SAPHNELO, tell your healthcare provider about all of your medical conditions, including if you:
    •  Think you have an infection or have an infection that keeps coming back
    •  Are scheduled to receive a vaccination or if you think you may need a vaccination. You should not receive live vaccines during treatment with SAPHNELO
    •  Have or have had cancer
    •  Are receiving other biologic medicines or monoclonal antibodies
    •  Are pregnant or plan to become pregnant. It is not known if SAPHNELO will harm your unborn baby. Tell your healthcare provider if you are, might be, or plan to become pregnant during treatment with SAPHNELO
      • Pregnancy exposure registry monitors pregnancy outcomes in women exposed to SAPHNELO. You can find out more information about the registry by calling AstraZeneca at 1-877-693-9268
    •  Are breastfeeding or plan to breastfeed. It is not known if SAPHNELO passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SAPHNELO may affect the way other medicines work, and other medicines may affect how SAPHNELO works.

SAPHNELO may cause serious side effects, including:

  • Serious infections: SAPHNELO can lower the ability of your immune system to fight infections. You may be at a higher risk of developing respiratory infections and shingles (herpes zoster) during treatment with SAPHNELO. Infections could be serious, leading to hospitalization or death. Tell your healthcare provider right away if you have any of the following symptoms of an infection:
    • fever, sweating, or chills
    • muscle aches
    • cough
    • shortness of breath
    • burning when urinating
    • urinating more often
    • diarrhea or stomach pain
    • warm, red, or painful skin or sores on your body
  • Allergic (hypersensitivity) reactions, including anaphylaxis: Serious allergic reactions can happen during or after SAPHNELO administration. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of a serious allergic reaction:
    •  swelling of your face, mouth, and tongue
    •  breathing problems
    •  fainting or dizziness
    •  feeling lightheaded (low blood pressure)
  • Cancer: SAPHNELO may reduce the activity of your immune system. Medicines that affect the immune system may increase your risk of certain cancers

The most common side effects of SAPHNELO include:

  •  Upper respiratory infections
  •  Bronchitis
  •  Infusion reactions (when given intravenously)
  •  Shingles (herpes zoster)
  •  Cough

These are not all the possible side effects of SAPHNELO. Call your healthcare provider for medical advice about side effects.

What is SAPHNELO?

SAPHNELO is a prescription medicine used to treat adults with moderate to severe systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines.

It is not known if SAPHNELO is effective in patients with severe active lupus nephritis or severe active central nervous system lupus. It is not known if SAPHNELO is safe and effective in patients under 18 years of age.

Please see full Prescribing Information, including Patient Information.

You may report side effects related to AstraZeneca productsOpens new window.

IMPORTANT SAFETY INFORMATION

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