BONNIE

Bonnie: You do kind of have to be your biggest cheerleader and your own biggest advocate about what you want to do for you.

Bonnie: Before diagnosis, pre-lupus Bonnie: active Philadelphia police officer. And when I say active, not behind the desk, I mean out there patrolling. DIY lover. Home Depot, Lowe's became my best friends. I love power tools. It felt like a slow burn, you know, kind of like that candlewick that just keeps burning. I lost a big part of what made me, me.

Bonnie: I spent years waiting for something to work that probably was never going to work for me. So, I spoke with my rheumatologist and I'm like, I want to try something. I'm hearing and reading great things about SAPHNELO. I understand what they were supposed to do; however, I feel like it put so much into my body and at the same time took so much out.

Bonnie: Now that my lupus is more under control because of SAPHNELO, I'm back. I'm doing things. The one thing that was just like, so amazing and like the best, one of the best parts for me, was the gradual elimination of steroids. I have been steroid free, not like doses every now and then, steroid free for so long, I can't even remember the last time I had a steroid.

Bonnie: Just one less medication, which in itself, just, it makes you feel your new normal, is a good new normal, is you again. After my first infusion with SAPHNELO, literally, no exaggeration, within weeks I felt results. Within weeks, I started to see, me again. I felt more like Bonnie again. It was like, "she's back."

Bonnie: My husband is probably not so happy about it, but I am definitely back to my DIYs. For the first time, your girl finished the walk, unassisted–I had never done that in years. In all the years we did the walks, I had never completed the walk, ever, without assistance. Do it for you.

Voiceover: For adults with moderate to severe SLE (lupus) on other lupus medicines. Not for severe active lupus nephritis or CNS lupus. Serious, sometimes fatal, infections have occurred. Seek medical attention right away if you have symptoms of allergic reactions (eg, swelling of face, mouth or tongue, breathing problems, dizziness). Serious allergic reactions can be delayed. Tell your doctor if you have/had cancer. Tell your doctor about side effects that may include upper respiratory infections, bronchitis, infusion reactions, shingles and cough. Do not use with other biologics or if allergic to SAPHNELO.

Please see full Prescribing Information, including Patient Information.

By completing this registration, I confirm that I am at least 18 years old, agree to receive information about SAPHNELO, and may receive information about other immunology medicines and services related to my condition which includes, but is not limited to, educational and promotional materials, special offers and services and for market research purposes, which includes contacting me to participate in focus groups, surveys or interviews. This may include AstraZeneca or a third party working on AstraZeneca's behalf contacting me by telephone, e-mail and text message regarding AstraZeneca Support Programs that may be of interest to me. Information provided by AstraZeneca does not take the place of talking to your healthcare provider about your treatment or condition. If you no longer want to receive health-related materials, call 1-800-236-9933. Please visit www.azprivacynotice.com to review our Privacy Notice.

By providing your phone number, you are opting in to receive updates and support messages from SAPHNELO. Text STOP to opt out. Text HELP for help. Message frequency will vary. Message and data rates may apply. For more information, visit Privacy Notice or Terms & Conditions.

IMPORTANT SAFETY INFORMATIONWhite CaratWhite Carat

  • Do not use SAPHNELO if you are allergic to anifrolumab-fnia or to any of the ingredients
  • Before you receive SAPHNELO, tell your healthcare provider about all of your medical conditions, including if you:
    •  Think you have an infection or have an infection that keeps coming back
    •  Are scheduled to receive a vaccination or if you think you may need a vaccination. You should not receive live vaccines during treatment with SAPHNELO
    •  Have or have had cancer
    •  Are receiving other biologic medicines or monoclonal antibodies
    •  Are pregnant or plan to become pregnant. It is not known if SAPHNELO will harm your unborn baby. Tell your healthcare provider if you are, might be, or plan to become pregnant during treatment with SAPHNELO
      • Pregnancy exposure registry monitors pregnancy outcomes in women exposed to SAPHNELO. You can find out more information about the registry by calling AstraZeneca at 1-877-693-9268
    •  Are breastfeeding or plan to breastfeed. It is not known if SAPHNELO passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SAPHNELO may affect the way other medicines work, and other medicines may affect how SAPHNELO works.

SAPHNELO may cause serious side effects, including:

  • Serious infections: SAPHNELO can lower the ability of your immune system to fight infections. You may be at a higher risk of developing respiratory infections and shingles (herpes zoster) during treatment with SAPHNELO. Infections could be serious, leading to hospitalization or death. Tell your healthcare provider right away if you have any of the following symptoms of an infection:
    • fever, sweating, or chills
    • muscle aches
    • cough
    • shortness of breath
    • burning when urinating
    • urinating more often
    • diarrhea or stomach pain
    • warm, red, or painful skin or sores on your body
  • Allergic (hypersensitivity) reactions, including anaphylaxis: Serious allergic reactions can happen during or after SAPHNELO administration. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of a serious allergic reaction:
    •  swelling of your face, mouth, and tongue
    •  breathing problems
    •  fainting or dizziness
    •  feeling lightheaded (low blood pressure)
  • Cancer: SAPHNELO may reduce the activity of your immune system. Medicines that affect the immune system may increase your risk of certain cancers

The most common side effects of SAPHNELO include:

  •  Upper respiratory infections
  •  Bronchitis
  •  Infusion reactions (when given intravenously)
  •  Shingles (herpes zoster)
  •  Cough

These are not all the possible side effects of SAPHNELO. Call your healthcare provider for medical advice about side effects.

What is SAPHNELO?

SAPHNELO is a prescription medicine used to treat adults with moderate to severe systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines.

It is not known if SAPHNELO is effective in patients with severe active lupus nephritis or severe active central nervous system lupus. It is not known if SAPHNELO is safe and effective in patients under 18 years of age.

Please see full Prescribing Information, including Patient Information.

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IMPORTANT SAFETY INFORMATION

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